ReMixT: clone-specific genomic structure estimation in cancer

ReMixT: clone-specific genomic structure estimation in cancer

Abstract Somatic evolution of malignant cells produces tumors composed of multiple clonal populations, distinguished in part by rearrangements and copy number changes affecting chromosomal segments. Whole genome sequencing mixes the signals of sampled populations, diluting the signals of clone-speci...

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Bibliographic Details
Main Authors: Andrew W. McPherson, Andrew Roth, Gavin Ha, Cedric Chauve, Adi Steif, Camila P. E. de Souza, Peter Eirew, Alexandre Bouchard-Côté, Sam Aparicio, S. Cenk Sahinalp, Sohrab P. Shah
Format: Article
Language:English
Published: BMC 2017-07-01
Series:Genome Biology
Subjects:
Cancer genomics
DNA sequencing
Tumour heterogeneity
Genomic rearrangement
Copy number variation
Online Access:http://link.springer.com/article/10.1186/s13059-017-1267-2

Internet

http://link.springer.com/article/10.1186/s13059-017-1267-2

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