A novel dimer-tetramer transition captured by the crystal structure of the HIV-1 Nef.

A novel dimer-tetramer transition captured by the crystal structure of the HIV-1 Nef.

HIV-1 Nef modulates disease progression through interactions with over 30 host proteins. Individual chains fold into membrane-interacting N-terminal and C-terminal core (Nef(core)) domains respectively. Nef exists as small oligomers near membranes and associates into higher oligomers such as tetrame...

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Bibliographic Details
Main Authors: Pankaj Singh, Gaya Prasad Yadav, Sudeepti Gupta, Anil Kumar Tripathi, Ravishankar Ramachandran, Raj Kamal Tripathi
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3206816?pdf=render

Internet

http://europepmc.org/articles/PMC3206816?pdf=render

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