Human monoclonal antibodies to a novel cluster of conformational epitopes on HCV E2 with resistance to neutralization escape in a genotype 2a isolate.

Human monoclonal antibodies to a novel cluster of conformational epitopes on HCV E2 with resistance to neutralization escape in a genotype 2a isolate.

The majority of broadly neutralizing antibodies to hepatitis C virus (HCV) are against conformational epitopes on the E2 glycoprotein. Many of them recognize overlapping epitopes in a cluster, designated as antigenic domain B, that contains residues G530 and D535. To gain information on other region...

Full description

Bibliographic Details
Main Authors: Zhen-yong Keck, Jinming Xia, Yong Wang, Wenyan Wang, Thomas Krey, Jannick Prentoe, Thomas Carlsen, Angela Ying-Jian Li, Arvind H Patel, Stanley M Lemon, Jens Bukh, Felix A Rey, Steven K H Foung
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS Pathogens
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/22511875/?tool=EBI

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/22511875/?tool=EBI

Similar Items