A novel role for Stat1 in phagosome acidification and natural host resistance to intracellular infection by Leishmania major.
Intracellular parasites of the genus Leishmania generate severe diseases in humans, which are associated with a failure of the infected host to induce a protective interferon gamma (IFNgamma)-mediated immune response. We tested the role of the JAK/STAT1 signaling pathway in Leishmania pathogenesis b...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2009-04-01
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| Series: | PLoS Pathogens |
| Online Access: | http://europepmc.org/articles/PMC2663844?pdf=render |