Factors Affecting Intracellular Delivery and Release of Hydrophilic Versus Hydrophobic Cargo from Mesoporous Silica Nanoparticles on 2D and 3D Cell Cultures

Factors Affecting Intracellular Delivery and Release of Hydrophilic Versus Hydrophobic Cargo from Mesoporous Silica Nanoparticles on 2D and 3D Cell Cultures

Intracellular drug delivery by mesoporous silica nanoparticles (MSNs) carrying hydrophilic and hydrophobic fluorophores as model drug cargo is demonstrated on 2D cellular and 3D tumor organoid level. Two different MSN designs, chosen on the basis of the characteristics of the loaded cargo, were used...

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Bibliographic Details
Main Authors: Diti Desai, Malin Åkerfelt, Neeraj Prabhakar, Mervi Toriseva, Tuomas Näreoja, Jixi Zhang, Matthias Nees, Jessica M. Rosenholm
Format: Article
Language:English
Published: MDPI AG 2018-11-01
Series:Pharmaceutics
Subjects:
intracellular delivery
mesoporous silica nanoparticles
cargo hydrophilicity
cargo hydrophobicity
cancer cells
cell labeling
organotypic 3D culture
live-cell imaging
Online Access:https://www.mdpi.com/1999-4923/10/4/237

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https://www.mdpi.com/1999-4923/10/4/237

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