Using hESCs to Probe the Interaction of the Diabetes-Associated Genes CDKAL1 and MT1E

Using hESCs to Probe the Interaction of the Diabetes-Associated Genes CDKAL1 and MT1E

Genome-wide association studies (GWASs) have identified many disease-associated variant alleles, but understanding whether and how different genes/loci interact requires a platform for probing how the variant alleles act mechanistically. Isogenic mutant human embryonic stem cells (hESCs) provide an...

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Bibliographic Details
Main Authors: Min Guo, Tuo Zhang, Xue Dong, Jenny Zhaoying Xiang, Minxiang Lei, Todd Evans, Johannes Graumann, Shuibing Chen
Format: Article
Language:English
Published: Elsevier 2017-05-01
Series:Cell Reports
Subjects:
metallothionein
CDKAL1
human pancreatic beta-like cells
directed differentiation
humanized mouse
chemical chaperones
endoplasmic reticulum stress
ER
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124717305995

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http://www.sciencedirect.com/science/article/pii/S2211124717305995

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