AGTR1 Is Overexpressed in Neuroendocrine Neoplasms, Regulates Secretion and May Potentially Serve as a Target for Molecular Imaging and Therapy

AGTR1 Is Overexpressed in Neuroendocrine Neoplasms, Regulates Secretion and May Potentially Serve as a Target for Molecular Imaging and Therapy

This study identified and confirmed angiotensin II (ATII) as a strong activator of signaling in neuroendocrine neoplasm (NEN) cells. Expression analyses of the ATII receptor type 1 (AGTR1) revealed an upregulation of mRNA levels (RT-qPCR) and radioligand binding (autoradiography) in small-intestinal...

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Bibliographic Details
Main Authors: Samantha Exner, Claudia Schuldt, Sachindra Sachindra, Jing Du, Isabelle Heing-Becker, Kai Licha, Bertram Wiedenmann, Carsten Grötzinger
Format: Article
Language:English
Published: MDPI AG 2020-10-01
Series:Cancers
Subjects:
neuroendocrine neoplasms
AGTR1
overexpression
signaling
secretion
imaging
Online Access:https://www.mdpi.com/2072-6694/12/11/3138

Internet

https://www.mdpi.com/2072-6694/12/11/3138

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