Piperine Attenuates Pathological Cardiac Fibrosis Via PPAR-γ/AKT Pathways

Piperine Attenuates Pathological Cardiac Fibrosis Via PPAR-γ/AKT Pathways

Mitogen-activated protein kinases (MAPKs) and AMP­activated protein kinase α (AMPKα) play critical roles in the process of cardiac hypertrophy. Previous studies have demonstrated that piperine activates AMPKα and reduces the phosphorylation of extracellular signal-regulated kinase (ERK). However, th...

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Bibliographic Details
Main Authors: Zhen-Guo Ma, Yu-Pei Yuan, Xin Zhang, Si-Chi Xu, Sha-Sha Wang, Qi-Zhu Tang
Format: Article
Language:English
Published: Elsevier 2017-04-01
Series:EBioMedicine
Subjects:
Piperine
Fibrosis
Cardiac fibroblast
PPAR-γ
AKT
Online Access:http://www.sciencedirect.com/science/article/pii/S2352396417301172

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http://www.sciencedirect.com/science/article/pii/S2352396417301172

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