Attenuation of CD4+CD25+ Regulatory T Cells in the Tumor Microenvironment by Metformin, a Type 2 Diabetes Drug

Attenuation of CD4+CD25+ Regulatory T Cells in the Tumor Microenvironment by Metformin, a Type 2 Diabetes Drug

CD4+CD25+ regulatory T cells (Treg), an essential subset for preventing autoimmune diseases, is implicated as a negative regulator in anti-tumor immunity. We found that metformin (Met) reduced tumor-infiltrating Treg (Ti-Treg), particularly the terminally-differentiated CD103+KLRG1+ population, and...

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Bibliographic Details
Main Authors: Yuki Kunisada, Shingo Eikawa, Nahoko Tomonobu, Shohei Domae, Takenori Uehara, Shohei Hori, Yukihiro Furusawa, Koji Hase, Akira Sasaki, Heiichiro Udono
Format: Article
Language:English
Published: Elsevier 2017-11-01
Series:EBioMedicine
Subjects:
Tumor immunity
Tumor microenvironment
Regulatory T cell (Treg)
Glycolysis
mTOR
Online Access:http://www.sciencedirect.com/science/article/pii/S235239641730405X

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http://www.sciencedirect.com/science/article/pii/S235239641730405X

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