Coronary artery disease genes SMAD3 and TCF21 promote opposing interactive genetic programs that regulate smooth muscle cell differentiation and disease risk.

Coronary artery disease genes SMAD3 and TCF21 promote opposing interactive genetic programs that regulate smooth muscle cell differentiation and disease risk.

Although numerous genetic loci have been associated with coronary artery disease (CAD) with genome wide association studies, efforts are needed to identify the causal genes in these loci and link them into fundamental signaling pathways. Recent studies have investigated the disease mechanism of CAD...

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Bibliographic Details
Main Authors: Dharini Iyer, Quanyi Zhao, Robert Wirka, Ameay Naravane, Trieu Nguyen, Boxiang Liu, Manabu Nagao, Paul Cheng, Clint L Miller, Juyong Brian Kim, Milos Pjanic, Thomas Quertermous
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2018-10-01
Series:PLoS Genetics
Online Access:http://europepmc.org/articles/PMC6198989?pdf=render

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http://europepmc.org/articles/PMC6198989?pdf=render

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