Hypermethylation of DMTN promotes the metastasis of colorectal cancer cells by regulating the actin cytoskeleton through Rac1 signaling activation

Hypermethylation of DMTN promotes the metastasis of colorectal cancer cells by regulating the actin cytoskeleton through Rac1 signaling activation

Abstract Background Colorectal cancer (CRC) is one of the most common digestive malignant tumors, and DMTN is a transcriptionally differentially expressed gene that was identified using CRC mRNA sequencing data from The Cancer Genome Atlas (TCGA). Our preliminary work suggested that the expression o...

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Bibliographic Details
Main Authors: Ya-Ping Ye, Hong-Li Jiao, Shu-Yang Wang, Zhi-Yuan Xiao, Dan Zhang, Jun-Feng Qiu, Ling-Jie Zhang, Ya-Li Zhao, Ting-Ting Li, Li-Liang, Wen-Ting Liao, Yan-Qing Ding
Format: Article
Language:English
Published: BMC 2018-12-01
Series:Journal of Experimental & Clinical Cancer Research
Subjects:
Colorectal cancer
DMTN
Metastasis
RAC1 signaling
Hypermethylation
Online Access:http://link.springer.com/article/10.1186/s13046-018-0958-1

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http://link.springer.com/article/10.1186/s13046-018-0958-1

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