Bioinformatic Analysis of Gene Variants from Gastroschisis Recurrence Identifies Multiple Novel Pathogenetic Pathways: Implication for the Closure of the Ventral Body Wall

Bioinformatic Analysis of Gene Variants from Gastroschisis Recurrence Identifies Multiple Novel Pathogenetic Pathways: Implication for the Closure of the Ventral Body Wall

We investigated whether likely pathogenic variants co-segregating with gastroschisis through a family-based approach using bioinformatic analyses were implicated in body wall closure. Gene Ontology (GO)/Panther functional enrichment and protein-protein interaction analysis by String identified sever...

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Bibliographic Details
Main Authors: Víctor M. Salinas-Torres, Hugo L. Gallardo-Blanco, Rafael A. Salinas-Torres, Ricardo M. Cerda-Flores, José J. Lugo-Trampe, Daniel Z. Villarreal-Martínez, Laura E. Martínez de Villarreal
Format: Article
Language:English
Published: MDPI AG 2019-05-01
Series:International Journal of Molecular Sciences
Subjects:
abdominal wall defect
alleles
bioinformatics
development
gastroschisis
genes
genetics
pathogenesis
recurrence
whole exome sequencing
Online Access:https://www.mdpi.com/1422-0067/20/9/2295

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https://www.mdpi.com/1422-0067/20/9/2295

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