EphrinB2 drives perivascular invasion and proliferation of glioblastoma stem-like cells

EphrinB2 drives perivascular invasion and proliferation of glioblastoma stem-like cells

Glioblastomas (GBM) are aggressive and therapy-resistant brain tumours, which contain a subpopulation of tumour-propagating glioblastoma stem-like cells (GSC) thought to drive progression and recurrence. Diffuse invasion of the brain parenchyma, including along preexisting blood vessels, is a leadin...

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Bibliographic Details
Main Authors: Benjamin Krusche, Cristina Ottone, Melanie P Clements, Ewan R Johnstone, Katrin Goetsch, Huang Lieven, Silvia G Mota, Poonam Singh, Sanjay Khadayate, Azhaar Ashraf, Timothy Davies, Steven M Pollard, Vincenzo De Paola, Federico Roncaroli, Jorge Martinez-Torrecuadrada, Paul Bertone, Simona Parrinello
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2016-06-01
Series:eLife
Subjects:
GBM
cancer stem cells
perivascular invasion
Eph/ephrin
Online Access:https://elifesciences.org/articles/14845

Internet

https://elifesciences.org/articles/14845

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