A novel piperine analogue exerts in vivo antitumor effect by inducing oxidative, antiangiogenic and immunomodulatory actions

A novel piperine analogue exerts in vivo antitumor effect by inducing oxidative, antiangiogenic and immunomodulatory actions

Structural diversity characterizes natural products as prototypes for design of lead compounds. The aim of this study was to synthetize, and to evaluate the toxicity and antitumor action of a new piperine analogue, the butyl 4-(4-nitrobenzoate)-piperinoate (DE-07). Toxicity was evaluated against zeb...

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Bibliographic Details
Main Authors: Rafael Carlos Ferreira, Tatianne Mota Batista, Sâmia Sousa Duarte, Daiana Karla Frade Silva, Thaís Mangeon Honorato Lisboa, Raquel Fragoso Pereira Cavalcanti, Fagner Carvalho Leite, Vivianne Mendes Mangueira, Tatyanna Kélvia Gomes de Sousa, Renata Albuquerque de Abrantes, Emmely Oliveira da Trindade, Petrônio Filgueiras de Athayde-Filho, Maria Cláudia Rodrigues Brandão, Karina Carla de Paula Medeiros, Davi Felipe Farias, Marianna Vieira Sobral
Format: Article
Language:English
Published: Elsevier 2020-08-01
Series:Biomedicine & Pharmacotherapy
Subjects:
Piperine analogue
Non-clinical toxicity
Zebrafish
Oxidative stress
Angiogenesis
Tumor microenvironment.
Online Access:http://www.sciencedirect.com/science/article/pii/S075333222030439X

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http://www.sciencedirect.com/science/article/pii/S075333222030439X

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