Intrathecal administration of a novel pyrazolyl-thiazole derivative induces delayed antinociception in mice

Intrathecal administration of a novel pyrazolyl-thiazole derivative induces delayed antinociception in mice

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In this study we investigated whether the intrathecal administration (i.t.) of the novel pyrazolyl-thiazole derivative 2-[5-trichloromethyl-5-hidroxy-3-phenyl-4,5-dihydro-1H-pyrazol-1-yl]-4-(4-bromophenyl)-5-methylthiazole (B50)  caused antinociception in adult male mice, using the hot plate and ace...

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Bibliographic Details
Main Authors: A. H. Souza, M. A. Rubin, P. D. Sauzem, G. S. Sant’Anna, G. D. Dalmolin, C.C. Drewes, M. N. Muniz, R. V. Lourega, H. G. Bonacorso, N. Zanatta, M. A. P. Martins, V. D. G. Sinhorin
Format: Article
Language:English
Published: Universidade Federal de Rondonópolis 2016-09-01
Series:Scientific Electronic Archives
Subjects:
intrathecal
antinociception
thiazole derivative
writhing test
hot-plate test
nonsteroidal anti-inflammatory drugs
Online Access:https://sea.ufr.edu.br/index.php?journal=SEA&page=article&op=view&path=370

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https://sea.ufr.edu.br/index.php?journal=SEA&page=article&op=view&path=370

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