Kallikrein-kinin blockade in patients with COVID-19 to prevent acute respiratory distress syndrome

Kallikrein-kinin blockade in patients with COVID-19 to prevent acute respiratory distress syndrome

COVID-19 patients can present with pulmonary edema early in disease. We propose that this is due to a local vascular problem because of activation of bradykinin 1 receptor (B1R) and B2R on endothelial cells in the lungs. SARS-CoV-2 enters the cell via ACE2 that next to its role in RAAS is needed to...

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Bibliographic Details
Main Authors: Frank L van de Veerdonk, Mihai G Netea, Marcel van Deuren, Jos WM van der Meer, Quirijn de Mast, Roger J Brüggemann, Hans van der Hoeven
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2020-04-01
Series:eLife
Subjects:
bradykinin
COVID-19
SARS
kinin
inflammation
icatibant
Online Access:https://elifesciences.org/articles/57555

Internet

https://elifesciences.org/articles/57555

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