Upregulated Expression of MicroRNA-204-5p Leads to the Death of Dopaminergic Cells by Targeting DYRK1A-Mediated Apoptotic Signaling Cascade

Upregulated Expression of MicroRNA-204-5p Leads to the Death of Dopaminergic Cells by Targeting DYRK1A-Mediated Apoptotic Signaling Cascade

MicroRNAs (miRs) downregulate or upregulate the mRNA level by binding to the 3′-untranslated region (3′UTR) of target gene. Dysregulated miR levels can be used as biomarkers of Parkinson’s disease (PD) and could participate in the etiology of PD. In the present study, 45 brain-enriched miRs were eva...

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Main Authors: Ching-Chi Chiu, Tu-Hsueh Yeh, Rou-Shayn Chen, Hua-Chien Chen, Ying-Zu Huang, Yi-Hsin Weng, Yi-Chuan Cheng, Yu-Chuan Liu, Ann-Joy Cheng, Ya-Ching Lu, Yu-Jie Chen, Yan-Wei Lin, Chia-Chen Hsu, Ying-Ling Chen, Chin-Song Lu, Hung-Li Wang
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-09-01
Series:Frontiers in Cellular Neuroscience
Subjects:
Parkinson’s disease
microRNA-204-5p
DYRK1A
ER stress
autophagy
apoptotic signaling
Online Access:https://www.frontiersin.org/article/10.3389/fncel.2019.00399/full

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https://www.frontiersin.org/article/10.3389/fncel.2019.00399/full

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