Silencing of lncRNA XIST impairs angiogenesis and exacerbates cerebral vascular injury after ischemic stroke

Silencing of lncRNA XIST impairs angiogenesis and exacerbates cerebral vascular injury after ischemic stroke

The aim of this study was to investigate the function and regulatory mechanism of long non-coding RNA (lncRNA) X-inactive-specific transcript (XIST) in cerebral ischemic stroke (CIS). The impact of lncRNA XIST on CIS was evaluated in acute CIS patients, middle cerebral artery occlusion (MCAO) mice,...

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Bibliographic Details
Main Authors: Cong Wang, Jing Dong, Jinru Sun, Shu Huang, Feifei Wu, Xinyu Zhang, Defang Pang, Yuan Fu, Longxuan Li
Format: Article
Language:English
Published: Elsevier 2021-12-01
Series:Molecular Therapy: Nucleic Acids
Subjects:
cerebral ischemic stroke
lncRNA
miR-92a
angiogenesis
blood-brain barrier
Online Access:http://www.sciencedirect.com/science/article/pii/S2162253121001682

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http://www.sciencedirect.com/science/article/pii/S2162253121001682

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