JAK2 exon 14 skipping in patients with primary myelofibrosis: a minor splice variant modulated by the JAK2-V617F allele burden.

JAK2 exon 14 skipping in patients with primary myelofibrosis: a minor splice variant modulated by the JAK2-V617F allele burden.

Primary myelofibrosis (PMF) is an acquired clonal disease of the hematopoietic stem cell compartment, characterized by bone marrow fibrosis, anemia, splenomegaly and extramedullary hematopoiesis. About 60% of patients with PMF harbor a somatic mutation of the JAK2 gene (JAK2-V617F) in their hematopo...

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Bibliographic Details
Main Authors: Paolo Catarsi, Vittorio Rosti, Giacomo Morreale, Valentina Poletto, Laura Villani, Roberto Bertorelli, Matteo Pedrazzini, Michele Zorzetto, Giovanni Barosi, AGIMM investigators
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4305294?pdf=render

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http://europepmc.org/articles/PMC4305294?pdf=render

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