Tyrosine–Chlorambucil Conjugates Facilitate Cellular Uptake through <span style="font-variant: small-caps">L</span>-Type Amino Acid Transporter 1 (LAT1) in Human Breast Cancer Cell Line MCF-7

Tyrosine–Chlorambucil Conjugates Facilitate Cellular Uptake through <span style="font-variant: small-caps">L</span>-Type Amino Acid Transporter 1 (LAT1) in Human Breast Cancer Cell Line MCF-7

<span style="font-variant: small-caps;">l</span>-type amino acid transporter 1 (LAT1) is an amino acid transporter that is overexpressed in several types of cancer and, thus, it can be a potential target for chemotherapy. The objectives of this study were to (a) synthesize LAT1...

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Bibliographic Details
Main Authors: Piman Pocasap, Natthida Weerapreeyakul, Juri Timonen, Juulia Järvinen, Jukka Leppänen, Jussi Kärkkäinen, Jarkko Rautio
Format: Article
Language:English
Published: MDPI AG 2020-03-01
Series:International Journal of Molecular Sciences
Subjects:
at1
cancer
chlorambucil
cellular uptake
antiproliferative
mcf-7
Online Access:https://www.mdpi.com/1422-0067/21/6/2132

Internet

https://www.mdpi.com/1422-0067/21/6/2132

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