Comparison of normalization methods for the analysis of metagenomic gene abundance data

Comparison of normalization methods for the analysis of metagenomic gene abundance data

Abstract Background In shotgun metagenomics, microbial communities are studied through direct sequencing of DNA without any prior cultivation. By comparing gene abundances estimated from the generated sequencing reads, functional differences between the communities can be identified. However, gene a...

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Bibliographic Details
Main Authors: Mariana Buongermino Pereira, Mikael Wallroth, Viktor Jonsson, Erik Kristiansson
Format: Article
Language:English
Published: BMC 2018-04-01
Series:BMC Genomics
Subjects:
Shotgun metagenomics
Gene abundances
Normalization
High-dimensional data
Systematic variability
False discovery rate
Online Access:http://link.springer.com/article/10.1186/s12864-018-4637-6

Internet

http://link.springer.com/article/10.1186/s12864-018-4637-6

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