The Plasmodium PI(4)K inhibitor KDU691 selectively inhibits dihydroartemisinin-pretreated Plasmodium falciparum ring-stage parasites

The Plasmodium PI(4)K inhibitor KDU691 selectively inhibits dihydroartemisinin-pretreated Plasmodium falciparum ring-stage parasites

Abstract Malaria control and elimination are threatened by the emergence and spread of resistance to artemisinin-based combination therapies (ACTs). Experimental evidence suggests that when an artemisinin (ART)-sensitive (K13 wild-type) Plasmodium falciparum strain is exposed to ART derivatives such...

Full description

Bibliographic Details
Main Authors: L. Dembele, X. Ang, M. Chavchich, G. M. C. Bonamy, J. J. Selva, M. Yi-Xiu Lim, C. Bodenreider, B. K. S. Yeung, F. Nosten, B. M. Russell, M. D. Edstein, J. Straimer, D. A. Fidock, T. T. Diagana, P. Bifani
Format: Article
Language:English
Published: Nature Publishing Group 2017-05-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-017-02440-6

Internet

https://doi.org/10.1038/s41598-017-02440-6

Similar Items