Lymph node stromal cells constrain immunity via MHC class II self-antigen presentation
Non-hematopoietic lymph node stromal cells shape immunity by inducing MHC-I-dependent deletion of self-reactive CD8+ T cells and MHC-II-dependent anergy of CD4+ T cells. In this study, we show that MHC-II expression on lymph node stromal cells is additionally required for homeostatic maintenance of...
Main Authors: | , , , , , , , , , , , , |
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Format: | Article |
Language: | English |
Published: |
eLife Sciences Publications Ltd
2014-11-01
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Series: | eLife |
Subjects: | |
Online Access: | https://elifesciences.org/articles/04433 |