Paracrine Interactions between Adipocytes and Tumor Cells Recruit and Modify Macrophages to the Mammary Tumor Microenvironment: The Role of Obesity and Inflammation in Breast Adipose Tissue

Paracrine Interactions between Adipocytes and Tumor Cells Recruit and Modify Macrophages to the Mammary Tumor Microenvironment: The Role of Obesity and Inflammation in Breast Adipose Tissue

The relationship between obesity and breast cancer (BC) has focused on serum factors. However, the mammary gland contains adipose tissue (AT) which may enable the crosstalk between adipocytes and tumor cells contributing to tumor macrophage recruitment. We hypothesize that the breast AT (bAT) is inf...

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Bibliographic Details
Main Authors: Ana M. Santander, Omar Lopez-Ocejo, Olivia Casas, Thais Agostini, Lidia Sanchez, Eduardo Lamas-Basulto, Roberto Carrio, Margot P. Cleary, Ruben R. Gonzalez-Perez, Marta Torroella-Kouri
Format: Article
Language:English
Published: MDPI AG 2015-01-01
Series:Cancers
Subjects:
breast cancer
obesity
breast adipose tissue
inflammation
tumor microenvironment
macrophages
adipocytes
breast tumor cells
chemotaxis
diet-induced obesity
tumor progression
Online Access:http://www.mdpi.com/2072-6694/7/1/143

Internet

http://www.mdpi.com/2072-6694/7/1/143

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