Large-Fragment Deletions Induced by Cas9 Cleavage while Not in the BEs System

Large-Fragment Deletions Induced by Cas9 Cleavage while Not in the BEs System

CRISPR-Cas9 and base editors (BEs) systems are poised to become the gene-editing tool of choice in clinical contexts; however, large-fragment deletion was found in Cas9-mediated mutation cells and mice. In this study, by analyzing 16 gene-edited rabbit lines (including 112 rabbits) generated using S...

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Bibliographic Details
Main Authors: Yuning Song, Zhiquan Liu, Yuxin Zhang, Mao Chen, Tingting Sui, Liangxue Lai, Zhanjun Li
Format: Article
Language:English
Published: Elsevier 2020-09-01
Series:Molecular Therapy: Nucleic Acids
Subjects:
large-fragment deletion
CRISPR-Cas9
BEs
rabbits
xCas9
xCas9-BEs
Online Access:http://www.sciencedirect.com/science/article/pii/S2162253120301803

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http://www.sciencedirect.com/science/article/pii/S2162253120301803

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