Riproximin Exhibits Diversity in Sugar Binding, and Modulates some Metastasis-Related Proteins with Lectin like Properties in Pancreatic Ductal Adenocarcinoma

Riproximin Exhibits Diversity in Sugar Binding, and Modulates some Metastasis-Related Proteins with Lectin like Properties in Pancreatic Ductal Adenocarcinoma

Riproximin (Rpx) is a type II ribosome-inactivating protein with specific anti-proliferative activity. It was purified from Ximenia americana by affinity chromatography using a resin coupled with lactosyl residues. The same technique facilitated isolation of proteins with lectin-like properties from...

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Bibliographic Details
Main Authors: Micah N. Sagini, Karel D. Klika, Andrew Orry, Michael Zepp, Joshua Mutiso, Martin R. Berger
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-11-01
Series:Frontiers in Pharmacology
Subjects:
Pancreatic ductal adenocarcinoma
lactosyl-sepharose binding proteins
cellular lectins
ribosome-inactivating protein
monosaccharides
affinity
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2020.549804/full

Internet

https://www.frontiersin.org/articles/10.3389/fphar.2020.549804/full

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