Direct Targeting of CREB1 with Imperatorin Inhibits TGFβ2‐ERK Signaling to Suppress Esophageal Cancer Metastasis

Direct Targeting of CREB1 with Imperatorin Inhibits TGFβ2‐ERK Signaling to Suppress Esophageal Cancer Metastasis

Abstract Metastasis accounts for 90% of cancer death worldwide, and effective therapeutic strategies are lacking. The aim of this work is to identify the key drivers in tumor metastasis and screen therapeutics for treatment of esophageal squamous cell carcinoma (ESCC). Gene Ontology analysis of The...

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Bibliographic Details
Main Authors: Wen Wen Xu, Zhi‐Hao Huang, Long Liao, Qi‐Hua Zhang, Jun‐Qi Li, Can‐Can Zheng, Yan He, Ting‐Ting Luo, Yang Wang, Hui‐Fang Hu, Qian Zuo, Wen‐You Chen, Qing‐Sheng Yang, Jian‐Fu Zhao, Yan‐Ru Qin, Li‐Yan Xu, En‐Min Li, Hua‐Xin Liao, Bin Li, Qing‐Yu He
Format: Article
Language:English
Published: Wiley 2020-08-01
Series:Advanced Science
Subjects:
diagnosis
esophageal cancer metastasis
Imperatorin
prognosis
TGFβ2
therapeutic implications
Online Access:https://doi.org/10.1002/advs.202000925

Internet

https://doi.org/10.1002/advs.202000925

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