Successful Treatment of Intracranial Glioblastoma Xenografts With a Monoamine Oxidase B-Activated Pro-Drug

Successful Treatment of Intracranial Glioblastoma Xenografts With a Monoamine Oxidase B-Activated Pro-Drug

The last major advance in the treatment of glioblastoma multiforme (GBM) was the introduction of temozolomide in 1999. Treatment with temozolomide following surgical debulking extends survival rate compared to radiotherapy and debulking alone. However, virtually all glioblastoma patients experience...

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Bibliographic Details
Main Authors: Martyn A. Sharpe, Andrew D. Livingston, Taylor L. Gist, Pardip Ghosh, Junyan Han, David S. Baskin
Format: Article
Language:English
Published: Elsevier 2015-09-01
Series:EBioMedicine
Subjects:
Glioblastoma multiforme
Monoamine oxidase B
Chemotherapy
Pro-drug
Xenograft
MP-MUS
Online Access:http://www.sciencedirect.com/science/article/pii/S2352396415301067

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http://www.sciencedirect.com/science/article/pii/S2352396415301067

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