Metformin for Clozapine Associated Obesity: A Systematic Review and Meta-Analysis.

BACKGROUND:Although clozapine is the gold-standard for treatment refractory schizophrenia, it has the worst metabolic profile of all antipsychotics. This is partly mediated by clozapine's impact on glucagon-like peptide (GLP-1). There is an absence of robust evidence for effective treatments fo...

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Bibliographic Details
Main Authors: Dan J Siskind, Janni Leung, Anthony W Russell, Daniel Wysoczanski, Steve Kisely
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2016-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4909277?pdf=render