Anti-heparanase aptamers as potential diagnostic and therapeutic agents for oral cancer.

Anti-heparanase aptamers as potential diagnostic and therapeutic agents for oral cancer.

Heparanase is an endoglycosidase enzyme present in activated leucocytes, mast cells, placental tissue, neutrophils and macrophages, and is involved in tumour metastasis and tissue invasion. It presents a potential target for cancer therapies and various molecules have been developed in an attempt to...

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Bibliographic Details
Main Authors: Suzanne C Simmons, Hannaleena Jämsä, Dilson Silva, Celia M Cortez, Edward A McKenzie, Carolina C Bitu, Sirpa Salo, Sini Nurmenniemi, Pia Nyberg, Juha Risteli, Carlos E B deAlmeida, Paul E C Brenchley, Tuula Salo, Sotiris Missailidis
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4189786?pdf=render

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http://europepmc.org/articles/PMC4189786?pdf=render

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