Erythropoietin attenuates pulmonary vascular remodeling in experimental pulmonary arterial hypertension through interplay between endothelial progenitor cells and heme-oxygenase

Erythropoietin attenuates pulmonary vascular remodeling in experimental pulmonary arterial hypertension through interplay between endothelial progenitor cells and heme-oxygenase

BackgroundPulmonary arterial hypertension (PAH) is a pulmonary vascular disease with a high mortality, characterized by typical angio-proliferative lesions. Erythropoietin (EPO) attenuates pulmonary vascular remodeling in PAH. We postulated that EPO acts through mobilization of endothelial progenito...

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Bibliographic Details
Main Authors: Rosa L.E. Loon, Beatrijs eBartelds, Frank A.D.T.G. Wagener, Nada eAffara, Saffloer eMohaupt, Hans eWijnberg, Sebastiaan W.C. Pennings, Janny eTakens, Rolf M.F. Berger
Format: Article
Language:English
Published: Frontiers Media S.A. 2015-08-01
Series:Frontiers in Pediatrics
Subjects:
Heme Oxygenase-1
endothelial progenitor cells
pulmonary hypertension
right ventricular dysfunction
Neointimal Hyperplasia
Pulmonary vascular remodeling
Online Access:http://journal.frontiersin.org/Journal/10.3389/fped.2015.00071/full

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http://journal.frontiersin.org/Journal/10.3389/fped.2015.00071/full

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