Gsα-dependent signaling is required for postnatal establishment of a functional β-cell mass

Gsα-dependent signaling is required for postnatal establishment of a functional β-cell mass

Objective: Early postnatal life is a critical period for the establishment of the functional β-cell mass that will sustain whole-body glucose homeostasis during the lifetime. β cells are formed from progenitors during embryonic development but undergo significant expansion in quantity and attain fun...

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Bibliographic Details
Main Authors: Berta Serra-Navarro, Rebeca Fernandez-Ruiz, Ainhoa García-Alamán, Marta Pradas-Juni, Eduardo Fernandez-Rebollo, Yaiza Esteban, Joan Mir-Coll, Julia Mathieu, Stephane Dalle, Max Hahn, Ulf Ahlgren, Lee S. Weinstein, Josep Vidal, Ramon Gomis, Rosa Gasa
Format: Article
Language:English
Published: Elsevier 2021-11-01
Series:Molecular Metabolism
Subjects:
β-Cell mass
cAMP
Gs
Insulin signaling
Cell maturation
Postnatal development
Online Access:http://www.sciencedirect.com/science/article/pii/S2212877821001095

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http://www.sciencedirect.com/science/article/pii/S2212877821001095

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