The Anti-Tumor Agent Sodium Selenate Decreases Methylated PP2A, Increases GSK3βY216 Phosphorylation, Including Tau Disease Epitopes and Reduces Neuronal Excitability in SHSY-5Y Neurons

The Anti-Tumor Agent Sodium Selenate Decreases Methylated PP2A, Increases GSK3βY216 Phosphorylation, Including Tau Disease Epitopes and Reduces Neuronal Excitability in SHSY-5Y Neurons

Selenium application as sodium selenate was repeatedly shown to have anti-carcinogenic properties by increasing levels of the serine/ threonine protein phosphatase 2A (PP2A) in cancer cells. PP2A has a prominent role in cell development, homeostasis, and in neurons regulates excitability. PP2A, GSK3...

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Bibliographic Details
Main Authors: Wesal Habbab, Imad Aoudé, Freshteh Palangi, Sara Abdulla, Tariq Ahmed
Format: Article
Language:English
Published: MDPI AG 2019-02-01
Series:International Journal of Molecular Sciences
Subjects:
PP2A
GSK3β
Tau
retinoic acid differentiated SHSY-5Y cells
Online Access:https://www.mdpi.com/1422-0067/20/4/844

Internet

https://www.mdpi.com/1422-0067/20/4/844

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