Tumor NLRP3-Derived IL-1β Drives the IL-6/STAT3 Axis Resulting in Sustained MDSC-Mediated Immunosuppression

Tumor NLRP3-Derived IL-1β Drives the IL-6/STAT3 Axis Resulting in Sustained MDSC-Mediated Immunosuppression

Tumors evade the immune system by inducing inflammation. In melanoma, tumor-derived IL-1β drives inflammation and the expansion of highly immunosuppressive myeloid-derived suppressor cells (MDSCs). Similar in many tumors, melanoma is also linked to the downstream IL‐6/STAT3 axis. In this study, we o...

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Bibliographic Details
Main Authors: Isak W. Tengesdal, Alberto Dinarello, Nicholas E. Powers, Matthew A. Burchill, Leo A. B. Joosten, Carlo Marchetti, Charles A. Dinarello
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-08-01
Series:Frontiers in Immunology
Subjects:
interleukin-1β
NLRP3
interleukin-6
signal transducer and activator of transcription 3
myeloid-derived suppressor cells
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.661323/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2021.661323/full

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