Novel Alzheimer risk genes determine the microglia response to amyloid‐β but not to TAU pathology

Novel Alzheimer risk genes determine the microglia response to amyloid‐β but not to TAU pathology

Abstract Polygenic risk scores have identified that genetic variants without genome‐wide significance still add to the genetic risk of developing Alzheimer's disease (AD). Whether and how subthreshold risk loci translate into relevant disease pathways is unknown. We investigate here the involve...

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Bibliographic Details
Main Authors: Annerieke Sierksma, Ashley Lu, Renzo Mancuso, Nicola Fattorelli, Nicola Thrupp, Evgenia Salta, Jesus Zoco, David Blum, Luc Buée, Bart De Strooper, Mark Fiers
Format: Article
Language:English
Published: Wiley 2020-03-01
Series:EMBO Molecular Medicine
Subjects:
Alzheimer's disease
genetic risk
microglia
RNA‐seq
single cell
Online Access:https://doi.org/10.15252/emmm.201910606

Internet

https://doi.org/10.15252/emmm.201910606

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