Metabolic Linkage and Correlations to Storage Capacity in Erythrocytes from Glucose 6-Phosphate Dehydrogenase-Deficient Donors

Metabolic Linkage and Correlations to Storage Capacity in Erythrocytes from Glucose 6-Phosphate Dehydrogenase-Deficient Donors

ObjectiveIn glucose 6-phosphate dehydrogenase (G6PD) deficiency, decreased NADPH regeneration in the pentose phosphate pathway and subnormal levels of reduced glutathione result in insufficient antioxidant defense, increased susceptibility of red blood cells (RBCs) to oxidative stress, and acute hem...

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Bibliographic Details
Main Authors: Julie A. Reisz, Vassilis L. Tzounakas, Travis Nemkov, Artemis I. Voulgaridou, Issidora S. Papassideri, Anastasios G. Kriebardis, Angelo D’Alessandro, Marianna H. Antonelou
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-01-01
Series:Frontiers in Medicine
Subjects:
glucose 6-phosphate dehydrogenase deficiency
transfusion medicine
red blood cell storage lesion
donor variation
mass spectrometry
metabolomics
Online Access:http://journal.frontiersin.org/article/10.3389/fmed.2017.00248/full

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http://journal.frontiersin.org/article/10.3389/fmed.2017.00248/full

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