Alphavirus Replicon DNA Vectors Expressing Ebola GP and VP40 Antigens Induce Humoral and Cellular Immune Responses in Mice

Alphavirus Replicon DNA Vectors Expressing Ebola GP and VP40 Antigens Induce Humoral and Cellular Immune Responses in Mice

Ebola virus (EBOV) causes severe hemorrhagic fevers in humans, and no approved therapeutics or vaccine is currently available. Glycoprotein (GP) is the major protective antigen of EBOV, and can generate virus-like particles (VLPs) by co-expression with matrix protein (VP40). In this study, we constr...

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Bibliographic Details
Main Authors: Shoufeng Ren, Qimei Wei, Liya Cai, Xuejing Yang, Cuicui Xing, Feng Tan, Jianmei W. Leavenworth, Shaohui Liang, Wenquan Liu
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-01-01
Series:Frontiers in Microbiology
Subjects:
Ebola virus
GP and VP40 antigens
virus-like particles
SFV replicon vector
immune response
vaccine
Online Access:http://journal.frontiersin.org/article/10.3389/fmicb.2017.02662/full

Internet

http://journal.frontiersin.org/article/10.3389/fmicb.2017.02662/full

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