Targeting Mitochondrial Damage as a Therapeutic for Ileal Crohn’s Disease

Targeting Mitochondrial Damage as a Therapeutic for Ileal Crohn’s Disease

Paneth cell defects in Crohn’s disease (CD) patients (called the Type I phenotype) are associated with worse clinical outcomes. Recent studies have implicated mitochondrial dysfunction in Paneth cells as a mediator of ileitis in mice. We hypothesized that CD Paneth cells exhibit impaired mitochondri...

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Bibliographic Details
Main Authors: Kibrom M. Alula, Dakota N. Jackson, Andrew D. Smith, Daniel S. Kim, Kevin Turner, Elizabeth Odstrcil, Benny A. Kaipparettu, Themistocles Dassopoulos, K. Venuprasad, Linda A. Feagins, Arianne L. Theiss
Format: Article
Language:English
Published: MDPI AG 2021-05-01
Series:Cells
Subjects:
inflammatory bowel diseases
antioxidant
Type I Paneth cell phenotype
epithelial cells
Online Access:https://www.mdpi.com/2073-4409/10/6/1349

Internet

https://www.mdpi.com/2073-4409/10/6/1349

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