MicroRNA-17-92, a direct Ap-2α transcriptional target, modulates T-box factor activity in orofacial clefting.

MicroRNA-17-92, a direct Ap-2α transcriptional target, modulates T-box factor activity in orofacial clefting.

Among the most common human congenital anomalies, cleft lip and palate (CL/P) affects up to 1 in 700 live births. MicroRNA (miR)s are small, non-coding RNAs that repress gene expression post-transcriptionally. The miR-17-92 cluster encodes six miRs that have been implicated in human cancers and hear...

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Bibliographic Details
Main Authors: Jun Wang, Yan Bai, Hong Li, Stephanie B Greene, Elzbieta Klysik, Wei Yu, Robert J Schwartz, Trevor J Williams, James F Martin
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS Genetics
Online Access:http://europepmc.org/articles/PMC3777996?pdf=render

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http://europepmc.org/articles/PMC3777996?pdf=render

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