Dose-related liver injury of Geniposide associated with the alteration in bile acid synthesis and transportation

Dose-related liver injury of Geniposide associated with the alteration in bile acid synthesis and transportation

Abstract Fructus Gardenia (FG), containing the major active constituent Geniposide, is widely used in China for medicinal purposes. Currently, clinical reports of FG toxicity have not been published, however, animal studies have shown FG or Geniposide can cause hepatotoxicity in rats. We investigate...

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Bibliographic Details
Main Authors: Jingzhuo Tian, Jingjing Zhu, Yan Yi, Chunying Li, Yushi Zhang, Yong Zhao, Chen Pan, Shixie Xiang, Xiaolong Li, Guiqin Li, John W Newman, Xiaoyi Feng, Jing Liu, Jiayin Han, Lianmei Wang, Yue Gao, Michael R. La Frano, Aihua Liang
Format: Article
Language:English
Published: Nature Publishing Group 2017-08-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-017-09131-2

Internet

https://doi.org/10.1038/s41598-017-09131-2

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