Reduced syncytin-1 expression levels in placental syndromes correlates with epigenetic hypermethylation of the ERVW-1 promoter region.

Reduced syncytin-1 expression levels in placental syndromes correlates with epigenetic hypermethylation of the ERVW-1 promoter region.

Terminal differentiation of villous cytotrophoblasts (CT) ends in formation of the multinucleated syncytiotrophoblast representing the fetal-maternal interface. Aberrations during this cell-fusion process are associated with Intrauterine Growth Restriction (IUGR), Preeclampsia (PE) and High Elevated...

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Main Authors: Matthias Ruebner, Pamela L Strissel, Arif B Ekici, Elisabeth Stiegler, Ulf Dammer, Tamme W Goecke, Florian Faschingbauer, Fabian B Fahlbusch, Matthias W Beckmann, Reiner Strick
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3573012?pdf=render

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http://europepmc.org/articles/PMC3573012?pdf=render

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