Systemic Administration of Tempol Attenuates the Cardiorespiratory Depressant Effects of Fentanyl

Systemic Administration of Tempol Attenuates the Cardiorespiratory Depressant Effects of Fentanyl

Fentanyl is a high-potency opioid receptor agonist that elicits profound analgesia and suppression of breathing in humans and animals. To date, there is limited evidence as to whether changes in oxidant stress are important factors in any of the actions of acutely administered fentanyl. This study d...

Full description

Bibliographic Details
Main Authors: Santhosh Baby, Ryan Gruber, Joseph Discala, Veljko Puskovic, Nijo Jose, Feixiong Cheng, Michael Jenkins, James Seckler, Stephen Lewis
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-06-01
Series:Frontiers in Pharmacology
Subjects:
tempol
fentanyl
cardiorespiratory depression
superoxide dismutase
sprague-dawley rats
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2021.690407/full

Internet

https://www.frontiersin.org/articles/10.3389/fphar.2021.690407/full

Similar Items