Erythropoietin-Induced Changes in Bone and Bone Marrow in Mouse Models of Diet-Induced Obesity

Erythropoietin-Induced Changes in Bone and Bone Marrow in Mouse Models of Diet-Induced Obesity

Obesity remodels bone and increases bone marrow adipocytes (BMAT), which negatively regulate hematopoiesis and bone. Reduced BMAT could restore altered hematopoiesis and bone features. We analyzed the potential of erythropoietin (EPO), the cytokine required for erythropoiesis, to inhibit BMAT in C57...

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Bibliographic Details
Main Authors: Sukanya Suresh, Josue Caban Alvarez, Soumyadeep Dey, Constance Tom Noguchi
Format: Article
Language:English
Published: MDPI AG 2020-02-01
Series:International Journal of Molecular Sciences
Subjects:
erythropoietin
obesity
bone
bone marrow adipocyte
osteocyte
osteoblast
osteoclast
stromal cells
fgf23
Online Access:https://www.mdpi.com/1422-0067/21/5/1657

Internet

https://www.mdpi.com/1422-0067/21/5/1657

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