Antiproliferative and Immunoregulatory Effects of Azelaic Acid Against Acute Myeloid Leukemia via the Activation of Notch Signaling Pathway

Antiproliferative and Immunoregulatory Effects of Azelaic Acid Against Acute Myeloid Leukemia via the Activation of Notch Signaling Pathway

Acute myeloid leukemia (AML) is a common type of hematological malignancy that can progress rapidly. AML has a poor prognosis and a high incidence of relapse due to therapeutic resistance. Azelaic acid (AZA), a small molecular compound is known to exhibit antitumor effect on various tumor cells. Thi...

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Bibliographic Details
Main Authors: Zhang Dongdong, Yanxia Jin, Tian Yang, Qian Yang, Balu Wu, Yanling Chen, Ziyi Luo, Li Liang, Yunjiao Liu, Anjie Xu, Xiqin Tong, Can Can, Lu Ding, Honglei Tu, Yuxin Tan, Hongqiang Jiang, Xiaoyan Liu, Hui Shen, Li Liu, Yunbao Pan, Yongchang Wei, Fuling Zhou
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-11-01
Series:Frontiers in Pharmacology
Subjects:
azelaic acid
acute myeloid leukemia
immunoregulatory
Notch signaling pathway
Notch agonist
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2019.01396/full

Internet

https://www.frontiersin.org/article/10.3389/fphar.2019.01396/full

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