Expression of JAK3 Sensitive Na+ Coupled Glucose Carrier SGLT1 in Activated Cytotoxic T Lymphocytes

Expression of JAK3 Sensitive Na+ Coupled Glucose Carrier SGLT1 in Activated Cytotoxic T Lymphocytes

Background: Similar to tumor cells, activated T-lymphocytes generate ATP mainly by glycolytic degradation of glucose. Lymphocyte glucose uptake involves non-concentrative glucose carriers of the GLUT family. In contrast to GLUT isoforms, Na+-coupled glucose-carrier SGLT1 accumulates glucose against...

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Bibliographic Details
Main Authors: Shefalee K. Bhavsar, Yogesh Singh, Piyush Sharma, Vishal Khairnar, Zohreh Hosseinzadeh, Shaqiu Zhang, Monica Palmada, Ivan Sabolic, Hermann Koepsell, Karl S. Lang, Philipp A. Lang, Florian Lang
Format: Article
Language:English
Published: Cell Physiol Biochem Press GmbH & Co KG 2016-09-01
Series:Cellular Physiology and Biochemistry
Subjects:
Glucose uptake
Jurkat T cells
Energy depletion
Janus kinase
Tumor cells
Cytotoxic T lymphocytes
Online Access:http://www.karger.com/Article/FullText/447827

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http://www.karger.com/Article/FullText/447827

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