Isolation and prolonged expansion of oral mesenchymal stem cells under clinical-grade, GMP-compliant conditions differentially affects “stemness” properties

Isolation and prolonged expansion of oral mesenchymal stem cells under clinical-grade, GMP-compliant conditions differentially affects “stemness” properties

Abstract Background Development of clinical-grade cell preparations is central to meeting the regulatory requirements for cellular therapies under good manufacturing practice-compliant (cGMP) conditions. Since addition of animal serum in culture media may compromise safe and efficient expansion of m...

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Bibliographic Details
Main Authors: Athina Bakopoulou, Danae Apatzidou, Eleni Aggelidou, Evangelia Gousopoulou, Gabriele Leyhausen, Joachim Volk, Aristeidis Kritis, Petros Koidis, Werner Geurtsen
Format: Article
Language:English
Published: BMC 2017-11-01
Series:Stem Cell Research & Therapy
Subjects:
Oral mesenchymal stem cells
Alveolar bone marrow mesenchymal stem cells
Dental pulp stem cells
Clinical-grade expansion
Good manufacturing practice-compliant cell preparation
Prolonged expansion
Online Access:http://link.springer.com/article/10.1186/s13287-017-0705-0

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http://link.springer.com/article/10.1186/s13287-017-0705-0

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