Complementary Effects of Carbamylated and Citrullinated LL37 in Autoimmunity and Inflammation in Systemic Lupus Erythematosus

Complementary Effects of Carbamylated and Citrullinated LL37 in Autoimmunity and Inflammation in Systemic Lupus Erythematosus

LL37 acts as T-cell/B-cell autoantigen in Systemic lupus erythematosus (SLE) and psoriatic disease. Moreover, when bound to “self” nucleic acids, LL37 acts as “danger signal,” leading to type I interferon (IFN-I)/pro-inflammatory factors production. T-cell epitopes derived from citrullinated-LL37 ac...

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Bibliographic Details
Main Authors: Roberto Lande, Immacolata Pietraforte, Anna Mennella, Raffaella Palazzo, Francesca Romana Spinelli, Konstantinos Giannakakis, Francesca Spadaro, Mario Falchi, Valeria Riccieri, Katia Stefanantoni, Curdin Conrad, Cristiano Alessandri, Fabrizio Conti, Loredana Frasca
Format: Article
Language:English
Published: MDPI AG 2021-02-01
Series:International Journal of Molecular Sciences
Subjects:
LL37
post-translational modifications (PTM)
systemic lupus erythematosus (SLE)
Online Access:https://www.mdpi.com/1422-0067/22/4/1650

Internet

https://www.mdpi.com/1422-0067/22/4/1650

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