Inhibition of Tumor Growth, Angiogenesis, and Microcirculation by the Novel Flk-1 Inhibitor SU5416 as Assessed by Intravital Multi-fluorescence Videomicroscopy

Inhibition of Tumor Growth, Angiogenesis, and Microcirculation by the Novel Flk-1 Inhibitor SU5416 as Assessed by Intravital Multi-fluorescence Videomicroscopy

Vascular endothelial growth factor (VEGF) plays a fundamental role in mediating tumor angiogenesis and tumor growth. Here we investigate the direct effect of a novel small molecule inhibitor of the Flk-1-mediated signal transduction pathway of VEGF, SU5416, on tumor angiogenesis and microhemodynami...

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Bibliographic Details
Main Authors: Peter Vajkoczy, Michael D. Menger, Brigitte Vollmar, Lothar Schilling, Peter Schmiedek, K. Peter Hirth, Axel Ullrich, T.Annie T. Fong
Format: Article
Language:English
Published: Elsevier 1999-04-01
Series:Neoplasia: An International Journal for Oncology Research
Subjects:
antiangiogenic therapy
protein tyrosine kinase
glioma
vascularization
vascular endothelial growth factor (VEGF)
Online Access:http://www.sciencedirect.com/science/article/pii/S1476558699800335

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http://www.sciencedirect.com/science/article/pii/S1476558699800335

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