The study of targeted blocking SDF-1/CXCR4 signaling pathway with three antagonists on MMPs, type II collagen, and aggrecan levels in articular cartilage of guinea pigs

The study of targeted blocking SDF-1/CXCR4 signaling pathway with three antagonists on MMPs, type II collagen, and aggrecan levels in articular cartilage of guinea pigs

Abstract Objective To explore the possibility and mechanism of targeted blocking SDF-1/CXCR4 signaling pathway using three antagonists TN14003, T140, and AMD3100 in vivo, and to investigate the function of three antagonists in delay degeneration process of articular cartilage. Methods Ninety-six mal...

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Bibliographic Details
Main Authors: Guoliang Wang, Yanlin Li, Xuhan Meng, Xiao Yang, Yaoyu Xiang
Format: Article
Language:English
Published: BMC 2020-05-01
Series:Journal of Orthopaedic Surgery and Research
Subjects:
Osteoarthritis
Chondrocyte
Stromal cell derived factor-1(SDF-1)
Matrix metalloproteinase
Online Access:http://link.springer.com/article/10.1186/s13018-020-01646-1

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http://link.springer.com/article/10.1186/s13018-020-01646-1

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