Large-scale transcriptomic analysis reveals that pridopidine reverses aberrant gene expression and activates neuroprotective pathways in the YAC128 HD mouse

Large-scale transcriptomic analysis reveals that pridopidine reverses aberrant gene expression and activates neuroprotective pathways in the YAC128 HD mouse

Abstract Background Huntington Disease (HD) is an incurable autosomal dominant neurodegenerative disorder driven by an expansion repeat giving rise to the mutant huntingtin protein (mHtt), which is known to disrupt a multitude of transcriptional pathways. Pridopidine, a small molecule in development...

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Bibliographic Details
Main Authors: Rebecca Kusko, Jennifer Dreymann, Jermaine Ross, Yoonjeong Cha, Renan Escalante-Chong, Marta Garcia-Miralles, Liang Juin Tan, Michael E. Burczynski, Ben Zeskind, Daphna Laifenfeld, Mahmoud Pouladi, Michal Geva, Iris Grossman, Michael R. Hayden
Format: Article
Language:English
Published: BMC 2018-05-01
Series:Molecular Neurodegeneration
Subjects:
Huntington disease
Movement disorders
Neurodegeneration
Online Access:http://link.springer.com/article/10.1186/s13024-018-0259-3

Internet

http://link.springer.com/article/10.1186/s13024-018-0259-3

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